Endocrine Abstracts

Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).Objective: To determine the impact of IBD on pubertal status and pubertal growth.Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and b...

Introduction: Treatment with anti-TNFα therapy such as infliximab may improve growth in children with CD but the extent of improvement in growth and its relationship to pubertal progress and changes in glucocorticoid therapy are unclear.Aim: A retrospective study of growth, puberty and disease activity over the 6 months prior (T−6) to starting infliximab, at baseline (T0) and for the following 6 months (T+6) in CD. Results are expressed as med...

Background: The aetiology of delayed puberty in children with inflammatory bowel disease (IBD) is unclear.Methods: Retrospective analysis of 27 children with IBD with growth retardation and/or pubertal delay, who had basal LH and FSH (27) and LHRH stimulation test as part of clinical evaluation (25). Height velocity was converted to SDS for bone age for girls >11 years and boys >12 years to adjust for delayed puberty. Data expressed as median (ra...

Background: Whilst puberty is understood to be commonly effected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC), the extent of this effect as well as related problems with growth have rarely been quantified.Objective: To determine the impact of CD and UC on Size, Tempo and Velocity of the growth spurt.Methods: Retrospective study of 142 children with IBD (case notes available, 68) who fulfilled the criter...